Multi-platform, multi-region, multiple stages of AD pathology for open science discovery
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Neurodegenerative diseases arise from interactions between cells throughout the brain; they are not a cell- or regionally- autonomous process. The pathologies evolve from primary dysfunction through secondary pathology or adaptive changes. The Multi-‘omics Atlas Project, a UK DRI Director’s Initiative, aims to generate a well characterised, clinically annotated set of Alzheimer’s disease and control brain tissue collected using approaches harmonised across contributing brain banks. Multi-‘omics (e.g., genomics, transcriptomics, proteomics and lipidomics) data acquired across different brain regions and across different stages of the disease will be generated and tools for their characterisation will be available through an ‘open science’ platform to encourage collaborative science addressing major clinical challenges of dementia.
If you would like more information or to get involved with the project please contact [email protected]