Data
Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology
To better define roles that astrocytes and microglia play in Alzheimer's disease (AD), we used single-nuclei RNA-sequencing to comprehensively characterise transcriptomes in astrocyte and microglia nuclei selectively enriched during isolation post-mortem from neuropathologically defined AD and control brains with a range of amyloid-beta and phospho-tau (pTau) pathology.
Two brain regions were studied: entorhinal cortex (EC) and somatosensory cortex (SSC) and enriched for astrocytes ('astro'), microglia ('micro') and perivascular macrophages ('PerivascMacrophages').